The DISC1 promoter: characterization and regulation by FOXP2

The DISC1 promoter: characterization and regulation by FOXP2.

Disrupted in schizophrenia 1 (DISC1) is a leading candidate susceptibility gene for schizophrenia, bipolar disorder and recurrent major depression, which has been implicated in other psychiatric illnesses of neurodevelopmental origin, including autism. DISC1 was initially identified at the breakpoint of a balanced chromosomal translocation, t(1;11) (q42.1;14.3), in a family with a high incidenc...

Down Regulation of DHFR Promoter Activity by PML Transcription Repressor

Characterization of the human intestinal CD98 promoter and its regulation by interferon-

Yan Y, Dalmasso G, Sitaraman S, Merlin D. Characterization of the human intestinal CD98 promoter and its regulation by interferon. Am J Physiol Gastrointest Liver Physiol 292: G535–G545, 2007. First published October 5, 2006; doi:10.1152/ajpgi.00385.2006.—Growing evidence that epithelial CD98 plays an important role in intestinal inflammation focused our interest to investigate the transcriptio...

Identification and characterization of the Mustang promoter: regulation by AP-1 during myogenic differentiation.

We previously identified Mustang (musculoskeletal temporally activated novel gene) with expression exclusively in the musculoskeletal system. Although its expression is almost undetectable in intact bone, it is robustly upregulated during bone regeneration. It is also abundantly expressed in adult skeletal muscle and tendon. As such, Mustang represents a marker for these cells and thus identify...

Characterization of the human intestinal CD98 promoter and its regulation by interferon-gamma.

Growing evidence that epithelial CD98 plays an important role in intestinal inflammation focused our interest to investigate the transcriptional regulation of CD98. Our mouse-based in vivo and in vitro experiments revealed that epithelial colonic CD98 mRNA expression was transcriptionally increased in intestinal inflammation. We then isolated and characterized a 5'-flanking fragment containing ...